HIV-1 Specific IgA Detected in Vaginal Secretions of HIV Uninfected Women Participating in a Microbicide Trial in Southern Africa Are Primarily Directed Toward gp120 and gp140 Specificities
Identifieur interne : 002B20 ( Main/Exploration ); précédent : 002B19; suivant : 002B21HIV-1 Specific IgA Detected in Vaginal Secretions of HIV Uninfected Women Participating in a Microbicide Trial in Southern Africa Are Primarily Directed Toward gp120 and gp140 Specificities
Auteurs : Kelly E. Seaton [États-Unis] ; Lamar Ballweber [États-Unis] ; Audrey Lan [États-Unis] ; Michele Donathan [États-Unis] ; Sean Hughes [États-Unis] ; Lucia Vojtech [États-Unis] ; M. Anthony Moody [États-Unis] ; Hua-Xin Liao [États-Unis] ; Barton F. Haynes [États-Unis] ; Christine G. Galloway [États-Unis] ; Barbra A. Richardson [États-Unis] ; Salim Abdool Karim [Afrique du Sud, États-Unis] ; Charlene S. Dezzutti [États-Unis] ; M. Juliana Mcelrath [États-Unis] ; Georgia D. Tomaras [États-Unis] ; Florian Hladik [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Descripteurs français
- KwdFr :
- Analyse de variance, Anti-infectieux (immunologie), Anti-infectieux (usage thérapeutique), Anticorps anti-VIH (immunologie), Femelle, Humains, Immunité muqueuse (), Immunité muqueuse (immunologie), Immunoglobuline A (immunologie), Immunoglobuline G (immunologie), Infections à VIH (), Infections à VIH (diagnostic), Infections à VIH (immunologie), Produits du gène env du virus de l'immunodéficience humaine (immunologie), Projets pilotes, Protéine d'enveloppe gp120 du VIH (immunologie), Prélèvement biologique (), Prélèvement biologique (instrumentation), République d'Afrique du Sud, Sécrétions corporelles (immunologie), Sécrétions corporelles (virologie), Séronégativité VIH (immunologie), Séropositivité VIH (immunologie), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie), Vagin (immunologie), Vagin (virologie), Études de cohortes.
- MESH :
- diagnostic : Infections à VIH.
- immunologie : Anti-infectieux, Anticorps anti-VIH, Immunité muqueuse, Immunoglobuline A, Immunoglobuline G, Infections à VIH, Produits du gène env du virus de l'immunodéficience humaine, Protéine d'enveloppe gp120 du VIH, Sécrétions corporelles, Séronégativité VIH, Séropositivité VIH, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Vagin.
- usage thérapeutique : Anti-infectieux, Prélèvement biologique.
- virologie : Sécrétions corporelles, Vagin.
- Analyse de variance, Femelle, Humains, Immunité muqueuse, Infections à VIH, Projets pilotes, Prélèvement biologique, République d'Afrique du Sud, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Études de cohortes.
- Wicri :
- geographic : Afrique du Sud.
English descriptors
- KwdEn :
- Analysis of Variance, Anti-Infective Agents (immunology), Anti-Infective Agents (therapeutic use), Bodily Secretions (immunology), Bodily Secretions (virology), Cohort Studies, Female, HIV Antibodies (immunology), HIV Envelope Protein gp120 (immunology), HIV Infections (diagnosis), HIV Infections (immunology), HIV Infections (prevention & control), HIV Seronegativity (immunology), HIV Seropositivity (immunology), HIV-1 (drug effects), HIV-1 (immunology), Humans, Immunity, Mucosal (drug effects), Immunity, Mucosal (immunology), Immunoglobulin A (immunology), Immunoglobulin G (immunology), Pilot Projects, South Africa, Specimen Handling (instrumentation), Specimen Handling (methods), Vagina (immunology), Vagina (virology), env Gene Products, Human Immunodeficiency Virus (immunology).
- MESH :
- chemical , immunology : Anti-Infective Agents, HIV Antibodies, HIV Envelope Protein gp120, Immunoglobulin A, Immunoglobulin G, env Gene Products, Human Immunodeficiency Virus.
- chemical , therapeutic use : Anti-Infective Agents.
- geographic : South Africa.
- diagnosis : HIV Infections.
- drug effects : HIV-1, Immunity, Mucosal.
- immunology : Bodily Secretions, HIV Infections, HIV Seronegativity, HIV Seropositivity, HIV-1, Immunity, Mucosal, Vagina.
- instrumentation : Specimen Handling.
- methods : Specimen Handling.
- prevention & control : HIV Infections.
- virology : Bodily Secretions, Vagina.
- Analysis of Variance, Cohort Studies, Female, Humans, Pilot Projects.
Abstract
Many participants in microbicide trials remain uninfected despite ongoing exposure to HIV-1. Determining the emergence and nature of mucosal HIV-specific immune responses in such women is important, since these responses may contribute to protection and could provide insight for the rational design of HIV-1 vaccines.
We first conducted a pilot study to compare three sampling devices (Dacron swabs, flocked nylon swabs and Merocel sponges) for detection of HIV-1-specific IgG and IgA antibodies in vaginal secretions. IgG antibodies from HIV-1-positive women reacted broadly across the full panel of eight HIV-1 envelope (Env) antigens tested, whereas IgA antibodies only reacted to the gp41 subunit. No Env-reactive antibodies were detected in the HIV-negative women. The three sampling devices yielded equal HIV-1-specific antibody titers, as well as total IgG and IgA concentrations. We then tested vaginal Dacron swabs archived from 57 HIV seronegative women who participated in a microbicide efficacy trial in Southern Africa (HPTN 035). We detected vaginal IgA antibodies directed at HIV-1 Env gp120/gp140 in six of these women, and at gp41 in another three women, but did not detect Env-specific IgG antibodies in any women.
Vaginal secretions of HIV-1 infected women contained IgG reactivity to a broad range of Env antigens and IgA reactivity to gp41. In contrast, Env-binding antibodies in the vaginal secretions of HIV-1 uninfected women participating in the microbicide trial were restricted to the IgA subtype and were mostly directed at HIV-1 gp120/gp140.
Url:
DOI: 10.1371/journal.pone.0101863
PubMed: 25054205
PubMed Central: 4108330
Affiliations:
- Afrique du Sud, États-Unis
- Caroline du Nord, Pennsylvanie, Washington (État), État de New York
- New York, Seattle
- Université Columbia, Université de Washington
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Le document en format XML
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Tomaras</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Duke Human Vaccine Institute, Durham, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Durham, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Hladik, Florian" sort="Hladik, Florian" uniqKey="Hladik F" first="Florian" last="Hladik">Florian Hladik</name><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff8"><addr-line>Department of Medicine, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25054205</idno><idno type="pmc">4108330</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108330</idno><idno type="RBID">PMC:4108330</idno><idno type="doi">10.1371/journal.pone.0101863</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000153</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000153</idno><idno type="wicri:Area/Pmc/Curation">000153</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000153</idno><idno type="wicri:Area/Pmc/Checkpoint">001164</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001164</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002403</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002403</idno><idno type="wicri:Area/PubMed/Curation">002393</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002393</idno><idno type="wicri:Area/PubMed/Checkpoint">002393</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002393</idno><idno type="wicri:Area/Ncbi/Merge">002B69</idno><idno type="wicri:Area/Ncbi/Curation">002B69</idno><idno type="wicri:Area/Ncbi/Checkpoint">002B69</idno><idno type="wicri:Area/Main/Merge">002C45</idno><idno type="wicri:Area/Main/Curation">002B20</idno><idno type="wicri:Area/Main/Exploration">002B20</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">HIV-1 Specific IgA Detected in Vaginal Secretions of HIV Uninfected Women Participating in a Microbicide Trial in Southern Africa Are Primarily Directed Toward gp120 and gp140 Specificities</title><author><name sortKey="Seaton, Kelly E" sort="Seaton, Kelly E" uniqKey="Seaton K" first="Kelly E." last="Seaton">Kelly E. Seaton</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Duke Human Vaccine Institute, Durham, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Durham, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Ballweber, Lamar" sort="Ballweber, Lamar" uniqKey="Ballweber L" first="Lamar" last="Ballweber">Lamar Ballweber</name><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Lan, Audrey" sort="Lan, Audrey" uniqKey="Lan A" first="Audrey" last="Lan">Audrey Lan</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Duke Human Vaccine Institute, Durham, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Durham, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Donathan, Michele" sort="Donathan, Michele" uniqKey="Donathan M" first="Michele" last="Donathan">Michele Donathan</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Duke Human Vaccine Institute, Durham, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Durham, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Hughes, Sean" sort="Hughes, Sean" uniqKey="Hughes S" first="Sean" last="Hughes">Sean Hughes</name><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Vojtech, Lucia" sort="Vojtech, Lucia" uniqKey="Vojtech L" first="Lucia" last="Vojtech">Lucia Vojtech</name><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Moody, M Anthony" sort="Moody, M Anthony" uniqKey="Moody M" first="M. Anthony" last="Moody">M. Anthony Moody</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Duke Human Vaccine Institute, Durham, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Durham, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Liao, Hua Xin" sort="Liao, Hua Xin" uniqKey="Liao H" first="Hua-Xin" last="Liao">Hua-Xin Liao</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Duke Human Vaccine Institute, Durham, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Durham, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Haynes, Barton F" sort="Haynes, Barton F" uniqKey="Haynes B" first="Barton F." last="Haynes">Barton F. Haynes</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Duke Human Vaccine Institute, Durham, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Durham, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Galloway, Christine G" sort="Galloway, Christine G" uniqKey="Galloway C" first="Christine G." last="Galloway">Christine G. Galloway</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Richardson, Barbra A" sort="Richardson, Barbra A" uniqKey="Richardson B" first="Barbra A." last="Richardson">Barbra A. Richardson</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff4"><addr-line>Department of Biostatistics, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Karim, Salim Abdool" sort="Karim, Salim Abdool" uniqKey="Karim S" first="Salim Abdool" last="Karim">Salim Abdool Karim</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>CAPRISA - Centre for the AIDS Programme of Research in South Africa, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa</addr-line></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>CAPRISA - Centre for the AIDS Programme of Research in South Africa, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban</wicri:regionArea><wicri:noRegion>Durban</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff6"><addr-line>Department of Epidemiology, Columbia University, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Dezzutti, Charlene S" sort="Dezzutti, Charlene S" uniqKey="Dezzutti C" first="Charlene S." last="Dezzutti">Charlene S. Dezzutti</name><affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Mcelrath, M Juliana" sort="Mcelrath, M Juliana" uniqKey="Mcelrath M" first="M. Juliana" last="Mcelrath">M. Juliana Mcelrath</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff8"><addr-line>Department of Medicine, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff9"><addr-line>Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff10"><addr-line>Department of Global Health, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Global Health, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Tomaras, Georgia D" sort="Tomaras, Georgia D" uniqKey="Tomaras G" first="Georgia D." last="Tomaras">Georgia D. Tomaras</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Duke Human Vaccine Institute, Durham, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Durham, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Hladik, Florian" sort="Hladik, Florian" uniqKey="Hladik F" first="Florian" last="Hladik">Florian Hladik</name><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff8"><addr-line>Department of Medicine, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Anti-Infective Agents (immunology)</term><term>Anti-Infective Agents (therapeutic use)</term><term>Bodily Secretions (immunology)</term><term>Bodily Secretions (virology)</term><term>Cohort Studies</term><term>Female</term><term>HIV Antibodies (immunology)</term><term>HIV Envelope Protein gp120 (immunology)</term><term>HIV Infections (diagnosis)</term><term>HIV Infections (immunology)</term><term>HIV Infections (prevention & control)</term><term>HIV Seronegativity (immunology)</term><term>HIV Seropositivity (immunology)</term><term>HIV-1 (drug effects)</term><term>HIV-1 (immunology)</term><term>Humans</term><term>Immunity, Mucosal (drug effects)</term><term>Immunity, Mucosal (immunology)</term><term>Immunoglobulin A (immunology)</term><term>Immunoglobulin G (immunology)</term><term>Pilot Projects</term><term>South Africa</term><term>Specimen Handling (instrumentation)</term><term>Specimen Handling (methods)</term><term>Vagina (immunology)</term><term>Vagina (virology)</term><term>env Gene Products, Human Immunodeficiency Virus (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de variance</term><term>Anti-infectieux (immunologie)</term><term>Anti-infectieux (usage thérapeutique)</term><term>Anticorps anti-VIH (immunologie)</term><term>Femelle</term><term>Humains</term><term>Immunité muqueuse ()</term><term>Immunité muqueuse (immunologie)</term><term>Immunoglobuline A (immunologie)</term><term>Immunoglobuline G (immunologie)</term><term>Infections à VIH ()</term><term>Infections à VIH (diagnostic)</term><term>Infections à VIH (immunologie)</term><term>Produits du gène env du virus de l'immunodéficience humaine (immunologie)</term><term>Projets pilotes</term><term>Protéine d'enveloppe gp120 du VIH (immunologie)</term><term>Prélèvement biologique ()</term><term>Prélèvement biologique (instrumentation)</term><term>République d'Afrique du Sud</term><term>Sécrétions corporelles (immunologie)</term><term>Sécrétions corporelles (virologie)</term><term>Séronégativité VIH (immunologie)</term><term>Séropositivité VIH (immunologie)</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie)</term><term>Vagin (immunologie)</term><term>Vagin (virologie)</term><term>Études de cohortes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Anti-Infective Agents</term><term>HIV Antibodies</term><term>HIV Envelope Protein gp120</term><term>Immunoglobulin A</term><term>Immunoglobulin G</term><term>env Gene Products, Human Immunodeficiency Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Infective Agents</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>South Africa</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>HIV-1</term><term>Immunity, Mucosal</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anti-infectieux</term><term>Anticorps anti-VIH</term><term>Immunité muqueuse</term><term>Immunoglobuline A</term><term>Immunoglobuline G</term><term>Infections à VIH</term><term>Produits du gène env du virus de l'immunodéficience humaine</term><term>Protéine d'enveloppe gp120 du VIH</term><term>Sécrétions corporelles</term><term>Séronégativité VIH</term><term>Séropositivité VIH</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term><term>Vagin</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Bodily Secretions</term><term>HIV Infections</term><term>HIV Seronegativity</term><term>HIV Seropositivity</term><term>HIV-1</term><term>Immunity, Mucosal</term><term>Vagina</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Specimen Handling</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Specimen Handling</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anti-infectieux</term><term>Prélèvement biologique</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Sécrétions corporelles</term><term>Vagin</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Bodily Secretions</term><term>Vagina</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Pilot Projects</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de variance</term><term>Femelle</term><term>Humains</term><term>Immunité muqueuse</term><term>Infections à VIH</term><term>Projets pilotes</term><term>Prélèvement biologique</term><term>République d'Afrique du Sud</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term><term>Études de cohortes</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Afrique du Sud</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Many participants in microbicide trials remain uninfected despite ongoing exposure to HIV-1. Determining the emergence and nature of mucosal HIV-specific immune responses in such women is important, since these responses may contribute to protection and could provide insight for the rational design of HIV-1 vaccines.</p></sec><sec><title>Methods and Findings</title><p>We first conducted a pilot study to compare three sampling devices (Dacron swabs, flocked nylon swabs and Merocel sponges) for detection of HIV-1-specific IgG and IgA antibodies in vaginal secretions. IgG antibodies from HIV-1-positive women reacted broadly across the full panel of eight HIV-1 envelope (Env) antigens tested, whereas IgA antibodies only reacted to the gp41 subunit. No Env-reactive antibodies were detected in the HIV-negative women. The three sampling devices yielded equal HIV-1-specific antibody titers, as well as total IgG and IgA concentrations. We then tested vaginal Dacron swabs archived from 57 HIV seronegative women who participated in a microbicide efficacy trial in Southern Africa (HPTN 035). We detected vaginal IgA antibodies directed at HIV-1 Env gp120/gp140 in six of these women, and at gp41 in another three women, but did not detect Env-specific IgG antibodies in any women.</p></sec><sec><title>Conclusion</title><p>Vaginal secretions of HIV-1 infected women contained IgG reactivity to a broad range of Env antigens and IgA reactivity to gp41. In contrast, Env-binding antibodies in the vaginal secretions of HIV-1 uninfected women participating in the microbicide trial were restricted to the IgA subtype and were mostly directed at HIV-1 gp120/gp140.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hladik, F" uniqKey="Hladik F">F Hladik</name></author><author><name sortKey="Mcelrath, Mj" uniqKey="Mcelrath M">MJ McElrath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Royce, Ra" uniqKey="Royce R">RA Royce</name></author><author><name sortKey="Sena, A" uniqKey="Sena A">A Sena</name></author><author><name sortKey="Cates, W" uniqKey="Cates W">W Cates</name></author><author><name sortKey="Cohen, Ms" uniqKey="Cohen M">MS Cohen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shacklett, Bl" uniqKey="Shacklett B">BL Shacklett</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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uniqKey="Karuna S">ST Karuna</name></author><author><name sortKey="Mulligan, Mj" uniqKey="Mulligan M">MJ Mulligan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rerks Ngarm, S" uniqKey="Rerks Ngarm S">S Rerks-Ngarm</name></author><author><name sortKey="Pitisuttithum, P" uniqKey="Pitisuttithum P">P Pitisuttithum</name></author><author><name sortKey="Nitayaphan, S" uniqKey="Nitayaphan S">S Nitayaphan</name></author><author><name sortKey="Kaewkungwal, J" uniqKey="Kaewkungwal J">J Kaewkungwal</name></author><author><name sortKey="Chiu, J" uniqKey="Chiu J">J Chiu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haynes, Bf" uniqKey="Haynes B">BF Haynes</name></author><author><name sortKey="Gilbert, Pb" uniqKey="Gilbert P">PB Gilbert</name></author><author><name sortKey="Mcelrath, Mj" uniqKey="Mcelrath M">MJ McElrath</name></author><author><name sortKey="Zolla Pazner, S" uniqKey="Zolla Pazner S">S Zolla-Pazner</name></author><author><name sortKey="Tomaras, Gd" uniqKey="Tomaras G">GD Tomaras</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Afrique du Sud</li><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Pennsylvanie</li><li>Washington (État)</li><li>État de New York</li></region><settlement><li>New York</li><li>Seattle</li></settlement><orgName><li>Université Columbia</li><li>Université de Washington</li></orgName></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Seaton, Kelly E" sort="Seaton, Kelly E" uniqKey="Seaton K" first="Kelly E." last="Seaton">Kelly E. Seaton</name></region><name sortKey="Ballweber, Lamar" sort="Ballweber, Lamar" uniqKey="Ballweber L" first="Lamar" last="Ballweber">Lamar Ballweber</name><name sortKey="Dezzutti, Charlene S" sort="Dezzutti, Charlene S" uniqKey="Dezzutti C" first="Charlene S." last="Dezzutti">Charlene S. Dezzutti</name><name sortKey="Donathan, Michele" sort="Donathan, Michele" uniqKey="Donathan M" first="Michele" last="Donathan">Michele Donathan</name><name sortKey="Galloway, Christine G" sort="Galloway, Christine G" uniqKey="Galloway C" first="Christine G." last="Galloway">Christine G. Galloway</name><name sortKey="Haynes, Barton F" sort="Haynes, Barton F" uniqKey="Haynes B" first="Barton F." last="Haynes">Barton F. Haynes</name><name sortKey="Hladik, Florian" sort="Hladik, Florian" uniqKey="Hladik F" first="Florian" last="Hladik">Florian Hladik</name><name sortKey="Hladik, Florian" sort="Hladik, Florian" uniqKey="Hladik F" first="Florian" last="Hladik">Florian Hladik</name><name sortKey="Hladik, Florian" sort="Hladik, Florian" uniqKey="Hladik F" first="Florian" last="Hladik">Florian Hladik</name><name sortKey="Hughes, Sean" sort="Hughes, Sean" uniqKey="Hughes S" first="Sean" last="Hughes">Sean Hughes</name><name sortKey="Karim, Salim Abdool" sort="Karim, Salim Abdool" uniqKey="Karim S" first="Salim Abdool" last="Karim">Salim Abdool Karim</name><name sortKey="Lan, Audrey" sort="Lan, Audrey" uniqKey="Lan A" first="Audrey" last="Lan">Audrey Lan</name><name sortKey="Liao, Hua Xin" sort="Liao, Hua Xin" uniqKey="Liao H" first="Hua-Xin" last="Liao">Hua-Xin Liao</name><name sortKey="Mcelrath, M Juliana" sort="Mcelrath, M Juliana" uniqKey="Mcelrath M" first="M. Juliana" last="Mcelrath">M. Juliana Mcelrath</name><name sortKey="Mcelrath, M Juliana" sort="Mcelrath, M Juliana" uniqKey="Mcelrath M" first="M. Juliana" last="Mcelrath">M. Juliana Mcelrath</name><name sortKey="Mcelrath, M Juliana" sort="Mcelrath, M Juliana" uniqKey="Mcelrath M" first="M. Juliana" last="Mcelrath">M. Juliana Mcelrath</name><name sortKey="Mcelrath, M Juliana" sort="Mcelrath, M Juliana" uniqKey="Mcelrath M" first="M. Juliana" last="Mcelrath">M. Juliana Mcelrath</name><name sortKey="Moody, M Anthony" sort="Moody, M Anthony" uniqKey="Moody M" first="M. Anthony" last="Moody">M. Anthony Moody</name><name sortKey="Richardson, Barbra A" sort="Richardson, Barbra A" uniqKey="Richardson B" first="Barbra A." last="Richardson">Barbra A. Richardson</name><name sortKey="Richardson, Barbra A" sort="Richardson, Barbra A" uniqKey="Richardson B" first="Barbra A." last="Richardson">Barbra A. Richardson</name><name sortKey="Tomaras, Georgia D" sort="Tomaras, Georgia D" uniqKey="Tomaras G" first="Georgia D." last="Tomaras">Georgia D. Tomaras</name><name sortKey="Vojtech, Lucia" sort="Vojtech, Lucia" uniqKey="Vojtech L" first="Lucia" last="Vojtech">Lucia Vojtech</name></country><country name="Afrique du Sud"><noRegion><name sortKey="Karim, Salim Abdool" sort="Karim, Salim Abdool" uniqKey="Karim S" first="Salim Abdool" last="Karim">Salim Abdool Karim</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|area= PittsburghV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4108330
|texte= HIV-1 Specific IgA Detected in Vaginal Secretions of HIV Uninfected Women Participating in a Microbicide Trial in Southern Africa Are Primarily Directed Toward gp120 and gp140 Specificities
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25054205" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PittsburghV1
| This area was generated with Dilib version V0.6.38. |  |